According to early Islamic historians such as Ibn Ishaq, in honor of his ally, Negus Abraha built a great church at Sana'a known as al-Qullays, a loanword borrowed from εκκλησία "church".

Al-Qullays gained widespread fame, even gaining the notice of the Byzantine Empire.^[1] The Arab people of the time had their own center of religious worship and pilgrimage in Mecca, the Kaaba.^[1] Abraha attempted to divert their pilgrimage to al-Qullays and appointed a man named Muhammad ibn Khuza'i^{[citation needed]} to Mecca and Tihamah as a king with a message that al-Qullays was both much better than other houses of worship and purer, having not been defiled by the housing of idols.^[1]

Ibn Ishaq's Prophetic biography states:

With Abraha there were some Arabs who had come to seek his bounty, among them Muhammad ibn Khuza`i ibn Khuzaba al-Dhakwani, al-Sulami, with a number of his tribesmen including a brother of his called Qays. While they were with him a feast of Abraha occurred and he sent to invite them to the feast. Now he used to eat an animal's testicles, so when the invitation was brought they said, "By God, if we eat this the Arabs will hold it against us as long as we live."

Thereupon Muhammad ibn Khuza'i got up and went to Abraha and said, "O King, this is a festival of ours in which we eat only the loins and shoulders." Abraha replied that he would send them what they liked because his sole purpose in inviting them was to show that he honored them.

Then he crowned Muhammad ibn Khuza'i, and made him emir of Mudhar, and ordered him to go among the people to invite them to pilgrimage at his cathedral which he had built. When Muhammad ibn Khuza'i got as far as the land of Kinana, the people of the lowland, knowing what he had come for, sent a man of Hudhayl called ʿUrwa bin Hayyad al-Milasi, who shot him with an arrow, killing him. His brother Qays who was with him fled to Abraha and told him the news, which increased his rage and fury and he swore to raid the Kinana tribe and destroy the temple.

^{[citation needed]}

Ibn Ishaq further states that one of the men of the Quraysh tribe was angered by this, and going to Sana'a, slipped into the church at night and defiled it; it is widely assumed that he did so by defecating in it.

Abraha, incensed, launched an expedition of forty thousand men against the Ka‘bah at Mecca, led by a white elephant named Mahmud^[9] (and possibly with other elephants - some accounts state there were several elephants, or even as many as eight^[1][6]) in order to destroy the Ka‘bah. Several Arab tribes attempted to fight him on the way, but were defeated.

When news of the advance of Abraha's army came, the Arab tribes of the Quraysh, Banu Kinanah, Banu Khuza'a and Banu Hudhayl united in defense of the Ka‘bah. A man from the Himyarite Kingdom was sent by Abraha to advise them that Abraha only wished to demolish the Kaaba and if they resisted, they would be crushed. ‘Abdul Muttalib told the Meccans to seek refuge in the hills while he with some leading members of the Quraysh remained within the precincts of the Ka‘bah. Abraha sent a dispatch inviting Abdul-Muttalib to meet with Abraha and discuss matters. When Abdul-Muttalib left the meeting he was heard saying, "The Owner of this House is its Defender, and I am sure He will save it from the attack of the adversaries and will not dishonor the servants of His House."

The reference to the story in Qur’an is rather short. According to Surah al-Fil, the next day [as Abraha prepared to enter the city], a dark cloud of small birds named 'Ababil' (Arabic: أَبـابـيـل‎) appeared. The birds carried small rocks in their beaks, and bombarded the Ethiopian forces and smashed them like "eaten straw". However according to Muhammad Asad this surah does not describe birds literally carrying small rocks, he instead, referencing Al-Zamakhshari and Fakhr al-Din al-Razi translates the above mentioned verses as:

(2)Thus, He let loose upon them great swarms of flying creatures (3) which smote them with stone-hard blows of chastisement pre-ordained [10]

Mohammad Asad the words used in this verse, namely the "stones of sijjil", denote "a writing and, tropically, something that has been decreed [by God]".^[11] He further explains that this decree by god was a very sudden epidemic outbreak, which, according to Ibn Ishaq, caused fever (in arabic hasbah) and smallpox (arab. judari). This, as Asad concludes, points to the fact that the "stone hard blows of chastisement pre-ordained" were a very sudden virulent epidemic due to the fact that the word for fever "hasbah" primarily means "pelting [or smiting] with stones" in the famous arabic dictionary al-Qamous (القاموس) by Fairuzabadi.^[12][13] The word ta'ir can denote any "flying creature, whether bird or insect (Taj al-'Arus)".^[14]